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Staff Spotlight: Brian Mace

Friday, August 3, 2018
B Mace

Brian Mace first came to Duke Neurology in 1998, when he helped develop a mouse model to examine the association between APoE and Alzheimer’s disease. Now, his work to translate results from animal models into advances into practice continues in the Brain Injury Translational Research Laboratories. In this week’s “Staff Spotlight” interview, Mace talks to us about the changes he’s seen at Duke over the past 20 years (no more tram between Duke Hospital and Duke Clinics, for starters), his current work day, and how a recent study he contributed to helped cut costs and improve care at local community hospitals.

What are your current responsibilities within the Neurology Department? What does your typical day look like?
Currently I am a lab research analyst in the Brain Injury Translational Research Laboratories, here in the Neurology Department. My PIs are Dr. Bradley Kolls and Dr. Daniel Laskowitz, and the current laboratory focus that I am working on is the treatment of various injuries to the brain in animal models that we hope will translate to humans. These injuries include seizures, stroke, and traumatic brain injury to animals that test different therapeutic agents looking for desirable and beneficial results after injury. My typical day is dictated by the stage in which the animals are in at the time, from breeding, experimental procedures, testing after the procedure, running the assays to acquire the proper data, and then analyzing the data for interpretation and publication.

2018 will mark your 20th year at Duke. What was your first job when you came here?
I started in Neurology with Dr. Patrick Sullivan, developing the human Apolipoprotien E targeted replacement mouse model for Alzheimer’s disease.

What have been the biggest changes in at Duke since you came here?
The biggest changes at Duke since I have been here has been the removal of the old tram that traveled between Duke North and Duke South, and the new buildings of the Duke Cancer center, the Duke Medical Pavilion, the Trent Semans Center and the new building they are building outside my window.

You contributed to a recent article in Neurocritical Care that found examined the use of continuous video-electroencephalography in community hospitals. What were the main findings of the study?
Currently i am working on a number of basic science research papers, but this paper represents one of the clinical trials that I have been associated with. This study looked at bringing continuous video-electroencephalography (cvEEG) to a community hospital. ICU cvEEG service is feasible and practical to implement at the community hospital level. The service enhanced care and reduced transfers to a larger medical facility.

The system allowed for successful management of ICU patients with underlying seizures and eliminated interfaculty transfers to Duke. The results suggest cvEEG monitoring at community ICUs is practical, financially sustainable, and improves the level and quality of care, for the patients.

What passions or hobbies do you have outside of the Department?
Spending and doing thing with the family. Personally, I am a fan of the NFL, I am a diehard fan of the Chicago Bears, and I hope the ex-UNC QB, Mitchell Trubisky, puts the Bears back into the WIN column.

Mace rafting

In this photo, Mace and his family enjoy whitewater rafting in a river near the mountains of North Carolina.