As an neurointensivist with subspecialty training in cerebrovascular disease and neurocritical care my research focus is on the application of neurocritical care interventions to help patients with acute strokes and head injuries. My current research focuses both on improving and innovation of new therapies for patients with acute stroke as well as improving the systems of care that deliver life saving treatments to patients with stroke.
Current research studies include the use of neuroprotection strategies such as inhaled Nitric Oxide to protect the brain after removal of large vessel clots. I also involved in helping to develop and test new thrombolytic agents for use in acute stroke.
I am also working with a multidisciplinary team of systems of care experts at DCRI to re-engineer our stroke system of care across the heart of the Stroke Belt through a project called IMPROVE-Stroke Care which is leveraging novel informatics data systems to deliver state of the art care for patients with acute stroke.
I am also working with a number of colleagues in Neurology, Neurosurgery and Emergency medicine to apply the concept of system re-engineering to improve the outcomes of patients with acute traumatic brain injury in East Africa (Uganda, Kenya and Tanzania)
Education and Training
- Stroke Fellow, Medicineq, University of Western Ontario (Canada), 1992 - 1992
- Neurology Resident, Medicine, University of Western Ontario (Canada), 1988 - 1991
- Medical Resident, Medicine, University of Western Ontario (Canada), 1985 - 1988
- M.D., University of Western Ontario (Canada), 1985
Selected Grants and Awards
- IMPROVE Stroke Care Systems of Care Research Program
- Medtronic Stroke Initiative
- IMPROVE STROKE
- A Phase 1B/2. Multiccenter,Doubleblind Placebo-controlled, Randomized, Single-Ascending dose study to assess the safety, Pharmacokinetics and pharmacodynamics of DS-1040B in Subjects with Acute Ischemic Stroke.
- Secondary Stroke Prevention Study comparing Dabigatran vs Acetylsalicylic Acid in patients with Embolic Stroke of Undetermined Source RE-SPECT ESUS
- Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Efficacy and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal subarachnoid Hemorrhage
- A Phase 2,PlaceboControlled,Randomized,Double-Blind,Parallel-Arm Study to EvaluateEfficacy and Safety of BMS-986141For the Prevention of Recurrent Brain Infarction in Subjects receiving acetylsalicyclic acid(ASA)followingAcute Ischemic Stroke or TIA
- A Randomized, Double-Blind, MultiNational Study to Prevent Major Vascular Events with Ticagrelor Compared to Aspirin (ASA) in Patients with Acute Ischaemic Stroke or TIA (SOCRATES)
- Medically ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism RISK (MARINER)
determineTheTherEffectsOfNav guided 1HzRTMS Administered to Contralesional Hemisphere-Adjuvant to task-Oriented Rehabilitation inPts withIschemicorHemorr. Stroke.
- Phase 1/2 A Multicenter, Controlled, Randomized, Open-Label, Dose Escalation, Safety. Tolerability and Pharmocokinetic Study Comparing EG-1962 and Nimodipine in Patients with Aneurysmal Subarachnoid Hemorrhage.
- Transition of Care for Acute Stroke and Myocardial Infarction Patients
- Aging And Cognition After Cardiac Surgery