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Carol Anne Colton

Professor in Neurology
Campus mail: 201H Bryan Res Bldg, Durham, NC 27710
Phone: (919) 668-2758
Email address: carol.colton@duke.edu

Dr. Colton's research has centered on the study of chronic neurodegenerative diseases such as Alzheimer's disease. These diseases have a neuroinflammatory component involving the innate immune system in the CNS. Dr. Colton was among the first scientists to demonstrate that microglia are CNS macrophages and, like other tissue macrophages, respond to injury in the CNS by "killing" invading organisms. Microglia then help to orchestrate the "repair" process after injury. Recent research has focused on the regulation of microglial reactive oxygen species and reactive nitrogen species production as well as other cytoactive macrophage products that are made during the classical and alternative activation states associated with chronic neurodegeneration. Knowledge gained from the basic research program has been translated to the development of novel and extremely useful mouse models of Alzheimer's disease that enable pre-clinical testing of basic mechanisms and of potential therapeutics.

Education and Training

  • Ph.D., Rutgers University, 1973

Publications

Brown, CM, Bushnell, CD, Samsa, GP, Goldstein, LB, and Colton, CA. "Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke." Translational stroke research 6, no. 6 (December 2015): 430-436.

Scholars@Duke

Kan, MJ, Lee, JE, Wilson, JG, Everhart, AL, Brown, CM, Hoofnagle, AN, Jansen, M, Vitek, MP, Gunn, MD, and Colton, CA. "Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, no. 15 (April 2015): 5969-5982.

Scholars@Duke

Colton, CA, Wilson, JG, Everhart, A, Wilcock, DM, Puoliväli, J, Heikkinen, T, Oksman, J, Jääskeläinen, O, Lehtimäki, K, Laitinen, T, Vartiainen, N, and Vitek, MP. "mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models." Journal of Neuropathology & Experimental Neurology 73, no. 8 (August 2014): 752-769.

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Hoos, MD, Vitek, MP, Ridnour, LA, Wilson, J, Jansen, M, Everhart, A, Wink, DA, and Colton, CA. "The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment." Molecular neurodegeneration 9 (January 2014): 50-.

Scholars@Duke

Hoos, MD, Richardson, BM, Foster, MW, Everhart, A, Thompson, JW, Moseley, MA, and Colton, CA. "Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase." Journal of proteome research 12, no. 10 (October 2013): 4462-4477.

Scholars@Duke

Colton, CA. "Immune heterogeneity in neuroinflammation: dendritic cells in the brain." J Neuroimmune Pharmacol 8, no. 1 (March 2013): 145-162. (Review)

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Colton, CA. "Microglial-neuronal interactions during neurodegenerative diseases." J Neuroimmune Pharmacol 8, no. 1 (March 2013): 4-6.

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Colton, CA. "Immune heterogeneity in neuroinflammation: Dendritic cells in the brain." Journal of Neuroimmune Pharmacology 8, no. 1 (2013): 145-162.

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Ridnour, LA, Dhanapal, S, Hoos, M, Wilson, J, Lee, J, Cheng, RY, Brueggemann, EE, Hines, HB, Wilcock, DM, Vitek, MP, Wink, DA, and Colton, CA. "Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1." J Neurochem 123, no. 5 (December 2012): 736-749.

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Vitek, MP, Christensen, DJ, Wilcock, D, Davis, J, Van Nostrand, WE, Li, FQ, and Colton, CA. "APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics." Neurodegener Dis 10, no. 1-4 (2012): 122-126.

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