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Duke Neurology Research Round Up, June 2017

Friday, June 30, 2017
image courtesy NIH

Research Round up, June 2017

The past month saw twelve new studies written by faculty from the Duke Department of Neurology, from randomized controlled trials investigating new therapies for migraine and Parkinson’s disease, to descriptions of epilepsy in patients with specific types of diseases.

  • Mark Stacy, MD, was the senior author of a randomized, multicenter study examining the use of a potential new regimen for dyskinesia in Parkinson’s disease: topiramate with amantadine. Read their findings in Movement Disorders here.
  • Wolfgang Liedtke, MD, PhD, contributed to an article investigating the function of isopetasin, a component of the migraine treatment butterbur. Read that article in the British Journal of Pharmacology here.
  • Don Sanders, MD, and Janice Massey, MD, examined a new tool to evaluate clinical change in myasthenia gravis--the use of single-fiber electromyography to measure jitter, finding that changes in jitter corresponded to changes in the condition. Read their full article in Muscle and Nerve here.
  • M. Tariq Bhatti, MD, was the senior author of a case report describing a 66-year-old woman with a persistent “cloudy spot” in her left eye as well as progressive jaw pain. Read more about her symptoms and treatment in JAMA Ophthalmology.
  • Rod Radtke, MD, and Duke researchers including Bill Gallentine, MD, Mohamad Mikati, MD, wrote an article describing the characteristics of epilepsy in patients with neurofibromatosis type 1. Read their article in Epilepsy & Behavior here.
  • Incoming Clinical Neurophysiology Fellow Dmitry Tchapyjnikov, MD, was the lead author of a case report examining an adolescent’s immune-related neurological symptoms while receiving a checkpoint inhibitor used to treat some forms of cancer. Read what they found here.
  • Episodic migraines remain a source of intense disability for a large portion of the world’s population, but there are no fully satisfactory therapies available. Daniel Laskowitz, MD, MHS, and Deborah Attix, PhD, were part of a team conducting a randomized controlled trial that investigated a new treatment for this condition: caloric vestibular stimulation, finding steady declines in migraine over a three-month period. Read the full study in Headache here.
  • Miguel Nicolelis, PhD, was the senior author of a PNAS study examining how M1 and S1 neurons in Rhesus monkeys function, finding that the cells encode the feeling of reward as well as contributing to learning motor behavior. Read more about the findings and their significance here.
  • Lisa Hobson-Webb, MD, and recent alum Santoshi Billakota, MD, wrote a case report of a woman with with bilateral carpal tunnel syndrome status after nerve repair with a conduit for the Journal of Clinical Neurophysiology. Read their article here. 
  • Intracerebral stroke patients with previous exposure to combination antiplatelet therapy (CAPT) are at an increased risk for in-hospital mortality, according to a new Stroke study by Ying Xian, MD, PhD, and colleagues. Read that article here.
  • Xian also contributed to a large-scale study that examined whether transporting patients experiencing out-of-hospital cardiac arrest directly to percutaneous cardiac intervention (non-PCI) facilities improved outcomes. Read what they found in Circulation: Cardiovascular Quality and Outcomes here.
  • Michael Lutz, PhD, contributed to an Alzheimer’s and Dementia article examining how neuropathologies influenced the relationship between the TOMM40 ‘523 genotype and late-life cognitive decline. Read that article here.