The Liedtke laboratory attempts to understand how calcium influx regulates pain. This applies to both physiological pain, which is a healthy mechanism that has given patients a survival advantage, and to pathological pain, which can torment patients. Our lab focuses on trigeminal and other cranial nerve (glossopharyngeal) pain disorders. The Liedtke lab maintains a research agenda in sync with Dr. Liedtke’s clinical focus, using the methodology from molecular biology, physiology, and biomedical technologies. Because of the relevance for pain and nociception, pathophysiologically relevant modulatory co-stimuli such as inflammatory mediators are being considered. The laboratory also explores neural transmission mechanisms of such stimuli.