Our basic science research focuses on understanding the origins and mechanisms of epilepsy in the brain. This includes work on the genetic causes of epilepsy as well as understanding the biochemical pathways responsible for epilepsy. We are also using data from patients with epilepsy to improve our basic understanding of how the brain works.
Our translational work focuses on developing advanced tools to diagnose, treat, and cure epilepsy. This includes work on biomarkers in the blood to help with the diagnosis and classification of epilepsy and advanced imaging techniques to help identify parts of the brain responsible for seizures We are also currently developing new electrode technologies to better identify seizure onset zones for surgery and tools to modulate brain activity to prevent seizures
Run by Professor of Neurology Birgit Frauscher, MD, PhD, the Lab for Analytical Neurophysiology (ANPHY Lab) seeks to employ a variety of quantifiable tools in order to shed light on neurophysiological and pathological processes
Our clinical work investigates new techniques for the analysis of EEG and other data from patients with epilepsy, new drugs and devices for treatment of epilepsy, as well as quality and process improvements for a better quality of care for patients. The overall goal of the research program of the DCEC is to provide more extensive and better treatment opportunities for patients suffering from epilepsy.
To find information about clinical trials being done at Duke, please go to Clinicaltrials.gov
Birgit Frauscher's, MD, PhD Lab for Analytical Neurophysiology seeks to employ a variety of quantifiable tools in order to shed light on neurophysiological and pathological processes
The Cogan Lab studies speech, language, and cognition using invasive electrophysiological recordings (ECoG, SEEG, µECoG).
We use engineering approaches to understand and control neural function. Our research and development efforts are focused on devices that use electrical activation of the nervous system to restore function to individuals with neurological impairment.
Our research group seeks to improve the treatment of neurologic diseases and injuries. We study the development and function of neurons, one of the cellular components of brain circuits, as well as the neural signals that brain circuits produce.
Our research applies innovations in flexible electronics to create new technology for interfacing with the brain at a much finer scale and with broader coverage than previously possible. We create new tools for neuroscience research and technology to diagnose and treat neurological disorders, such as epilepsy.
The goal of this laboratory is to elucidate the cellular and molecular mechanisms underlying epileptogenesis, the process by which a normal brain becomes epileptic. The epilepsies constitute a group of common, serious neurological disorders, among which temporal lobe epilepsy (TLE) is the most prevalent and devastating.
Featuring:
Is Best Always Best? Patients' Preferences for Treatment Alternatives for Drug-resistant focal epilepsy by Shelby Reed, PhD, RPh, Professor of Population Health Sciences, Duke University
Brain Stimulation and Cognition in Epilepsy by Barbara C. Jobst, MD, Chair and Professor of Neurology, Dartmouth Geisel School of Medicine
DCEC Quarterly Research Symposium Spring 2022
Featuring:
EEG Source Imaging (ESI): Source modeling basics and more by Prachi T. Parikh, MD Assistant Professor of Neurology Duke University
Epileptiform activity at the microscale by Sydney S. Cash, M.D., Ph.D. Associate Professor of Neurology Massachusetts General Hospital and Harvard Medical School
DCEC Quarterly Research Symposium Winter 2021
Featuring:
Using Dynamical Network Models to Derive Interictal and Ictal Biomarkers of the Epileptogenic Zone from Intracranial EEG Data by Sridevi V. Sarma, PhD Associate Professor Biomedical Engineering, Johns Hopkins University
Non-invasive optical detection of brain activity using parallelized diffuse correlation spectroscopy by Roarke W. Horstmeyer, PhD Assistant Professor Biomedical Engineering, Duke University
DCEC Quarterly Research Symposium Fall 2021
Featuring:
Adding some science to the art of EEG: classifying seizure Dynamotypes by William Stacey, MD, PhD Associate Professor, Department of Neurology and Biomedical Engineering University of Michigan
DCEC Quarterly Research Symposium Summer 2021
Featuring:
The Measure by which you Measure: Quality of life and Quality of Care in Epilepsy by Matthew Luedke, MD Division Chief, Hospital Neurology Assistant Professor of Neurology Duke University
DCEC Quarterly Research Symposium Spring 2021
Featuring:
Beyond the focus – Why networks matter in temporal lobe epilepsy by Vicky Morgan, Ph.D. Professor of Radiology and Radiological Sciences Vanderbilt Universit
DCEC Quarterly Research Symposium Winter 2020
Featuring:
Using Ultrahigh-Resolution Diffusion MRI to Localize Seizure Foci in Patients with Intractable Epilepsy by Iain Bruce, PhD Medical Instructor Duke Department of Neurology
DCEC Quarterly Research Symposium Fall 2020
Featuring:
Augmented reality in epilepsy surgery and clinical application of source localization by Muhammad Zafar, MBBS Assistant Professor of Pediatrics Duke University
