I was first interested in neuroscience when I learned about neurons for the first time in middle school or high school. I remember being in disbelief when I learned that action potentials and the absence of action potentials were responsible for nearly everything that goes on in our brain. The idea that complex processes such as thought and learning are generated from combinations of action potentials among billions of neurons was fascinating to me, which is why I decided to major in neuroscience at Duke. While I have come to realize that we are a long way away from relating individual neurons to the generation of complex processes such as thought, I hope that cognitive neuroscience can continue to integrate more elements from neurobiology into its research to help provide a fuller understanding of the processes of our mysterious brain!
Chen Y, Wang ZL, Yeo M, Zhang QJ, López-Romero AE, Ding HP, Zhang X, Zeng Q, Morales-Lázaro SL, Moore C, Jin YA, Morstein J, Bortsov A, Krawczyk M, Lammert F, Abdelmalek M, Diehl AM, Milkiewicz P, Kremer AE, Zhang JY, Nackley A, Reeves TE, Ko MC, Ji RR, Rosenbaum T, Liedtke W. Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology. 2021 Jul;161(1):301-317.e16. doi: 10.1053/j.gastro.2021.03.049. Epub 2021 Apr 2. PMID: 33819485
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Chen Y, Moore CD, Zhang JY, Hall RP 3rd, MacLeod AS, Liedtke W. TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. Journal of Investigative Dermatology. 2017 Apr;137(4):801-804. doi: 10.1016/j.jid.2016.12.013. PMID: 28340683
Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW 4th, Wang F, Liedtke W. TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain. 2014 Dec;155(12):2662-2672. doi: 10.1016/j.pain.2014.09.033. Epub 2014 Oct 2. PMID: 25281928
Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB.UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proceedings of the National Academy of Science, U.S.A. 2013 Aug 20;110(34):E3225-34. doi: 10.1073/pnas.1312933110. Epub 2013 Aug 8. PMID: 23929777