The Duke Movement Disorders Clinic conducts a variety of clinical trials to continually seek out better treatments for those affected by movements disorders. If you are interested in participating in any of these trials, please email movdisres@dm.duke.edu.
Dystonia
- Dystonia Biomarker Discovery: This study hopes to identify blood "signatures" that indicate dystonia. The knowledge gained from this exploratory study may help improve diagnosis, identify subsets of dystonias that may respond to differing treatments, and/or create new opportunities to evaluate disease progression or treatment response. Participation involves completing a survey that provides information about your dystonia and having one routine blood draw.
- Accelerated TMS for Focal Hand Dystonia: This study is investigating the benefit of delivering multiple sessions of a non-invasive brain stimulation technique called transcranial magnetic stimulation to alleviate isolated symptoms of dystonia affecting the right hand or arm. Open for enrollment
- Accelerated TMS for Cervical Dystonia: This study is investigating the benefit of delivering a non-invasive brain stimulation technique called transcranial magnetic stimulation to alleviate isolated symptoms of dystonia affecting the neck. The study is especially seeking cervical dystonia patients considering the invasive deep brain stimulation surgery (DBS). Actively recruiting.
Huntington's Disease
- ENROLL-HD: ENROLL-HD is an observational study for patients with Huntington’s disease and their families.
Parkinson's Disease
- LUMA: This study is testing an oral medication that may slow the progression of Parkinson’s disease. Individuals with early-stage Parkinson’s disease (less than 2 years since diagnosis) between the ages of 30-80 may be eligible. There are multiple study visits over the course of up to 2.5 years.
- DBS Predictive Study: The study aims to evaluate Parkinson's disease patients considering deep brain stimulation (DBS) during OFF/ON evaluation. It involves collecting data points throughout the DBS workup and utilizing a smartwatch to track symptoms before and after the DBS procedure. The study involves two visits; one before the DBS procedure and another during the first DBS programming session.
- TOPAZ: This trial is testing if a bone-strengthening drug called zoledronic acid can help prevent debilitating hip fractures in Parkinson’s Disease. Study Contact: 1-800-473-4636 or visit www.topazstudy.org.
- SIS Vision: This trial is measuring the effectiveness of a new imaging guidance software on accurate placement of deep brain stimulation. Participation involves standard rating scales and brain images performed as part of routine clinical care for deep brain stimulation. There may be some additional rating scales performed as part of the study if they are not done as part of clinical care.
- Cerevance/ASCEND: This study is testing an oral medication called CVN424 in individuals diagnosed with Parkinson’s disease who are not yet receiving treatment for PD. The study will examine the potential of CVN424 to improve motor and non-motor function in early untreated PD. There are 7 in-person visits over this 14-week study.