The Duke Movement Disorders Clinic conducts a variety of clinical trials to continually seek out better treatments for those affected by movements disorders. If you are interested in participating in any of these trials, please email movdisres@dm.duke.edu.
Parkinson's Disease
- ExPDite (BlueRock): Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel - human embryonic stem cell [hESC]-derived midbrain dopaminergic [mDA] neuronal progenitor cells) for Participants With Parkinson’s Disease.
- PDGeneration: Is a nationwide program that provides free genetic testing for key Parkinson's-related genes, along with genetic counseling, for individuals diagnosed with Parkinson’s disease (PD). Participants can join remotely by enrolling online and using an at-home blood collection kit.
- Video Recording and Machine Learning Analysis of Movement Disorders: This study aims to use computer vision and machine learning to develop video-based quantitative metrics for movement disorder symptoms.
- Connectomic Guided DBS for Parkinson's Disease: This study aims to compare the effects on tremor and dyskinesia of clinically optimized deep brain stimulation during standard of care to image-based connectomic guided DBS defined settings in patients with Parkinson's disease.
- APPELLO (ACCOMPLISH) – An advanced PD study. This study is an oral medication used as add on therapy to levodopa in participants with moderate PD with motor fluctuations/wearing off. The study has 7 visits over 14 weeks.
Dystonia
- Dystonia Biomarker Discovery: This study aims to identify biomarkers for dystonia to improve diagnosis and guide treatment. We are especially seeking individuals with DYT1 and their family members, affected or not, to participate. The study involves a single visit of up to one hour, including a blood draw and a brief questionnaire.
- Accelerated TMS for Cervical Dystonia: This research aims to explore the efficacy of employing several sessions of transcranial magnetic stimulation, a non-invasive therapeutic method, to mitigate neck dystonia.
Huntington's Disease
- INVEST-HD: The purpose of the study is to compare the safety and efficacy of votoplam to a placebo in people with Huntington’s disease (HD). The study may last up to 36 months.
- PRECISE-HD: The purpose of this study is to evaluate the efficacy of pridopidine on clinical progression in participants with HD. The study may last up to 3 years and includes an open label extension.